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未麻醉大鼠正中隆起短期冷诱导促甲状腺激素释放激素（TRH）释放的直接证据。

Direct evidence of short-term cold-induced TRH release in the median eminence of unanesthetized rats.

作者信息

Arancibia S, Tapia-Arancibia L, Assenmacher I, Astier H

出版信息

Neuroendocrinology. 1983 Sep;37(3):225-8. doi: 10.1159/000123547.

DOI:10.1159/000123547
PMID:6413879
Abstract

IR-TRH release in the median eminence was directly estimated in conscious rats during the first 130 min of exposure to cold (4 degrees C), using a push-pull cannulation. A three-fold increase in IR-TRH release was observed, with a peak of 10.00 +/- 2.19 pg/15 min occurring 40 min after exposure to cold; control rats, left at 24 degrees C, stayed at the baseline secretion rate of 3.40 pg/15 min which was the sensitivity limit of the RIA assay.

摘要

在清醒大鼠暴露于寒冷（4℃）的最初130分钟内，使用推挽式插管法直接测定了正中隆起处的免疫反应性促甲状腺激素释放激素（IR-TRH）释放。观察到IR-TRH释放增加了三倍，暴露于寒冷40分钟后出现峰值，为10.00±2.19 pg/15分钟；置于24℃的对照大鼠维持在3.40 pg/15分钟的基础分泌率，这是放射免疫分析测定的灵敏度极限。

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