膳食中补充花生四烯酸会增加糖尿病患者血小板中血栓素的合成活性。

Dietary arachidonic acid supplementation increases thromboxane synthesizing activity in platelets from diabetics.

作者信息

Takahashi R, Morita I, Murota S, Shiraki M, Ito H, Orimo H

出版信息

Prostaglandins Leukot Med. 1983 Aug;11(4):443-50. doi: 10.1016/0262-1746(83)90098-7.

Abstract

Thromboxane A2 has been implicated in thrombotic vascular diseases. The diabetic population has a high incidence of vascular complications. In the present study, activity of thromboxane synthetase in platelets of type 2 (non-insulin dependent) diabetic patients was studied. Thromboxane synthesizing activity in diabetic platelets was significantly higher than that in controls (p less than 0.05). An effect of dietary arachidonic acid on thromboxane synthesizing activity in platelets was also studied. Dietary arachidonic acid supplementation containing 1.7g of arachidonic acid per day for 1 week caused a significant increase of arachidonic acid content in plasma total lipids (p less than 0.05), but the increase of arachidonic acid in plasma total lipids did not correlate with the level of arachidonic acid in platelet phospholipids. Thromboxane synthesizing activity in platelets from the diabetics and the controls was augmented by a diet enriched in arachidonic acid from 2.20 +/- 0.15 to 2.56 +/- 0.20 and from 1.71 +/- 0.23 to 2.01 +/- 0.34, respectively. The increase in diabetic subjects was statistically significant (p less than 0.05). These results suggest that fatty acids of dietary origin are important factors in development of thrombotic vascular diseases.

摘要

血栓素A2与血栓性血管疾病有关。糖尿病患者血管并发症的发生率很高。在本研究中，对2型（非胰岛素依赖型）糖尿病患者血小板中血栓素合成酶的活性进行了研究。糖尿病患者血小板中的血栓素合成活性显著高于对照组（p<0.05）。还研究了膳食花生四烯酸对血小板中血栓素合成活性的影响。每天补充含1.7g花生四烯酸的膳食1周，可使血浆总脂质中花生四烯酸含量显著增加（p<0.05），但血浆总脂质中花生四烯酸的增加与血小板磷脂中花生四烯酸的水平无关。富含花生四烯酸的饮食使糖尿病患者和对照组血小板中的血栓素合成活性分别从2.20±0.15增加到2.56±0.20，从1.71±0.23增加到2.01±0.34。糖尿病患者的增加具有统计学意义（p<0.05）。这些结果表明，膳食来源的脂肪酸是血栓性血管疾病发生发展的重要因素。