Caillé J M, Lemanceau B, Bonnemain B
AJNR Am J Neuroradiol. 1983 Sep-Oct;4(5):1041-2.
Gadolinium chloride (GdCl3) was studied as a contrast agent for nuclear magnetic resonance. This rare-earth element dramatically alters proton resonance (paramagnetic moment = 10.8 Bohr magnetons). Acute toxicity was determined by intravenous injections in mice; mean lethal dose was 100-200 mg of GdCl3 . 6 H2O/kg. Changes in T1 of plasma, kidney, liver, and brain of mice and rats were measured after intravenous injections of GdCl3 solution at a concentration of 60 mg gadolinium metal/kg. The apparatus used was a Wh 270 Brucker with a field of 63 kG. The T1 was found to be significantly decreased in plasma, kidney, and liver.
研究了氯化钆（GdCl3）作为核磁共振造影剂的情况。这种稀土元素会显著改变质子共振（顺磁矩 = 10.8 玻尔磁子）。通过给小鼠静脉注射来测定急性毒性；平均致死剂量为 100 - 200 mg GdCl3·6H2O/kg。以 60 mg 钆金属/kg 的浓度给小鼠和大鼠静脉注射 GdCl3 溶液后，测量其血浆、肾脏、肝脏和大脑的 T1 变化。所使用的仪器是场强为 63 kG 的 Wh 270 布鲁克仪器。发现血浆、肾脏和肝脏中的 T1 显著降低。
