载紫杉醇的白蛋白和透明质酸包覆超顺磁性氧化铁纳米粒子在生物医学中的应用。

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20131 Milano, Italy.

Biotechnology and Food Engineering Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel.

Molecules. 2017 Jun 22;22(7):1030. doi: 10.3390/molecules22071030.

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe₃O₄·DA-BSA/HA in water. Fe₃O₄·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe₃O₄·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.

超顺磁性氧化铁纳米粒子（SPION）通过透明质酸（HA）和牛血清白蛋白（BSA）增强，两者均通过多巴胺（DA）共价连接，从而将其锚定到 SPION 上。发现 HA 和 BSA 同时作为 Fe₃O₄·DA-BSA/HA 在水中的稳定聚合物。Fe₃O₄·DA-BSA/HA 可有效地包封并释放疏水性细胞毒性药物紫杉醇（PTX）。HA 和 BSA 的相对量不仅调节制剂的总溶解度，还调节顺磁弛豫性质。包封 PTX 不影响 Fe₃O₄·DA-BSA 的顺磁弛豫性质。因此，通过调整表面结构和负载，可以调整系统的治疗诊断性质。