Appel D, Rubenstein R, Schrager K, Williams M H
Am J Med. 1983 Oct;75(4):580-4. doi: 10.1016/0002-9343(83)90436-9.
Twelve patients with severe asthma in whom lactic acidosis developed are presented. All had an arterial blood pH level lower than that expected for the measured partial pressure of arterial carbon dioxide, all had an abnormally large anion gap, and the blood lactate level exceeded 2.8 mmol/liter. Respiratory acidosis subsequently developed in eight patients, and six required intubation. Lactic acidosis can develop in patients with severe asthma. Such patients are in danger of the development of respiratory failure and must be treated vigorously and observed closely.
本文报告了12例发生乳酸性酸中毒的重度哮喘患者。所有患者的动脉血pH值均低于根据测得的动脉二氧化碳分压所预期的值，均有异常增大的阴离子间隙，且血乳酸水平超过2.8 mmol/升。随后8例患者发生了呼吸性酸中毒，6例需要插管。重度哮喘患者可发生乳酸性酸中毒。这类患者有发生呼吸衰竭的危险，必须积极治疗并密切观察。
