Bentley J B, Conahan T J, Cork R C
Clin Pharmacol Ther. 1983 Nov;34(5):703-6. doi: 10.1038/clpt.1983.235.
Serum fentanyl concentrations were measured before, during, and after cardiopulmonary bypass and correlated with changes in total protein, albumin, hematocrit, pH, and PCO2 in five patients undergoing cardiac surgery. Serum fentanyl concentrations, total protein, albumin, and hematocrit declined with initiation of bypass but remained unchanged thereafter. PCO2 and pH did not change. In an additional seven patients, simultaneous pulmonary-artery and radial-artery fentanyl concentrations were measured. During bypass, when little, if any blood flowed through the pulmonary circulation, pulmonary artery fentanyl concentrations were higher than systemic arterial concentrations, but when lung ventilation and perfusion were restored, radial artery concentrations rose and pulmonary artery concentrations fell, indicating fentanyl sequestration in the lungs during bypass.
在五名接受心脏手术的患者中，测量了体外循环前、期间和之后的血清芬太尼浓度，并将其与总蛋白、白蛋白、血细胞比容、pH值和PCO2的变化进行关联。体外循环开始时，血清芬太尼浓度、总蛋白、白蛋白和血细胞比容下降，但此后保持不变。PCO2和pH值没有变化。在另外七名患者中，同时测量了肺动脉和桡动脉的芬太尼浓度。在体外循环期间，当几乎没有（如果有的话）血液流经肺循环时，肺动脉芬太尼浓度高于体动脉浓度，但当肺通气和灌注恢复时，桡动脉浓度上升而肺动脉浓度下降，表明体外循环期间芬太尼在肺中潴留。
