Lee J S, Trowsdale J, Travers P, Bodmer W F
Hum Immunol. 1983 Sep;8(1):105-12. doi: 10.1016/0198-8859(83)90088-5.
Analysis of the amino acid sequence of the HLA-DR alpha chain and the structure of the gene encoding it have shown strong homologies to membrane proximal domains of the DR beta chain and HLA-ABC, as well as to beta 2-microglobulin. Weaker, but nevertheless apparent homologies to C kappa and C lambda immunoglobulin domains support the interpretation that these genes diverged in evolution from a primordial immunoglobulin-like domain. Cosmid clones containing sequences related to the DR alpha chain have been isolated. These sequences probably represent the SB and DC alpha genes. In addition to the alpha "genes," some of the cosmids also contain sequences related to the DR beta chain suggesting that the human HLA-D region alpha and beta genes are interspersed.
对HLA - DRα链的氨基酸序列及其编码基因结构的分析表明，它与DRβ链和HLA - ABC的膜近端结构域以及β2 - 微球蛋白具有很强的同源性。与Cκ和Cλ免疫球蛋白结构域的同源性较弱但仍很明显，这支持了这些基因在进化过程中从原始免疫球蛋白样结构域分化而来的解释。已经分离出含有与DRα链相关序列的黏粒克隆。这些序列可能代表SB和DCα基因。除了α“基因”外，一些黏粒还含有与DRβ链相关的序列，这表明人类HLA - D区域的α和β基因是交错排列的。
