Bourne R G, Kearsley J H, Grove W D, Roberts S J
Int J Radiat Oncol Biol Phys. 1983 Oct;9(10):1445-50. doi: 10.1016/0360-3016(83)90316-4.
In a retrospective analysis of 1,390 consecutive patients with carcinoma of the cervix treated by high dose radiation therapy alone at the Queensland Radium Institute, we report a quantitative relationship between the early and late gastrointestinal complications arising from such treatment. Of these 1,390 patients, 157 (11.3%) experienced early, serious complications. For geographic reasons, it was only possible to evaluate 784 patients for late post-irradiation complications. Twenty-eight (3.6%) developed one or more late bowel complications, which included adhesions, fistulae, strictures, perforation, colitis and vascular occlusion. Factors affecting the relative risk of developing either an early or late complication were analyzed and are discussed. There was an 8.2% incidence of late complications developing in those patients who had experienced early complications, compared with a 3.0% incidence of late complications developing in patients without early complications. Thus, the risk of developing a late complication was greater by a factor of 2.7 in those patients developing an early one (p less than 0.05). However, of the 28 patients developing late complications, 21 (75%) did not experience a severe acute one.
在对昆士兰镭研究所仅接受高剂量放射治疗的1390例连续宫颈癌患者进行的回顾性分析中，我们报告了此类治疗引起的早期和晚期胃肠道并发症之间的定量关系。在这1390例患者中，157例（11.3%）出现了早期严重并发症。由于地理原因，仅对784例患者进行了放疗后晚期并发症评估。28例（3.6%）出现一种或多种晚期肠道并发症，包括粘连、瘘管、狭窄、穿孔、结肠炎和血管阻塞。分析并讨论了影响发生早期或晚期并发症相对风险的因素。出现早期并发症的患者中晚期并发症发生率为8.2%，而未出现早期并发症的患者中晚期并发症发生率为3.0%。因此，出现早期并发症的患者发生晚期并发症的风险高出2.7倍（p<0.05）。然而，在出现晚期并发症的28例患者中，21例（75%）未经历严重急性并发症。
