赖氨酸密码子的抑制子可能是错酰化的赖氨酸tRNA。
Suppressors of lysine codons may be misacylated lysine tRNAs.
作者信息
Murgola E J, Pagel F T
出版信息
J Bacteriol. 1983 Nov;156(2):917-9. doi: 10.1128/jb.156.2.917-919.1983.
Abstract
We describe a novel class of missense suppressors that read the codons for lysine at two positions (211 and 234) in the trpA polypeptide of Escherichia coli. The suppressor mutations are highly linked to lysT, a gene for lysine tRNA. The results suggest that the suppressors are misacylated lysine tRNAs that carry glycine or alanine. The mutant codons are apparently suppressed better at position 211 than at position 234, indicating the existence of codon context effects in missense suppression.
摘要
我们描述了一类新型错义抑制子，它们能识别大肠杆菌色氨酸合成酶A（trpA）多肽中两个位置（211和234）的赖氨酸密码子。这些抑制子突变与赖氨酸tRNA的基因lysT高度连锁。结果表明，这些抑制子是携带甘氨酸或丙氨酸的错酰化赖氨酸tRNA。突变密码子在211位的抑制效果明显优于234位，这表明错义抑制中存在密码子上下文效应。
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本文引用的文献
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