Wong P N, Wilson D F
J Oral Pathol. 1983 Oct;12(5):375-84. doi: 10.1111/j.1600-0714.1983.tb00350.x.
Most reported studies of experimental oral cancer have been carried out in the hamster. This animal is not available in certain countries and there is controversy regarding its suitability as a model for experimental oral carcinogenesis. An attempt was made to reproduce an experimental oral cancer model in rats, using a protocol based on that described by Lekholm and Wallenius (1976). The carcinogen 4 nitroquinoline 1-oxide was applied to the palates of rats for periods of up to 24 weeks. Macroscopic and microscopic examination of carcinogen-treated palatal mucosa was carried out during the experimental period. Verrucous carcinoma-like lesions of the mid-palate and squamous carcinomas of the gingival mucosa were produced, beginning at 16 and 20 weeks respectively. A variety of other macroscopic and microscopic mucosal changes were also observed during the experimental period. The findings are discussed in relation to the work of others.
大多数已报道的实验性口腔癌研究是在仓鼠身上进行的。在某些国家无法获得这种动物，并且对于它作为实验性口腔癌发生模型的适用性存在争议。我们尝试使用基于Lekholm和Wallenius（1976年）所描述的方案，在大鼠身上重现实验性口腔癌模型。将致癌物质4-硝基喹啉-1-氧化物应用于大鼠的腭部，持续时间长达24周。在实验期间对经致癌物处理的腭部黏膜进行了宏观和微观检查。分别在第16周和第20周开始出现腭中部的疣状癌样病变和牙龈黏膜的鳞状癌。在实验期间还观察到了各种其他宏观和微观的黏膜变化。结合其他人的工作对这些发现进行了讨论。
