Nakajima T, Ota K, Ishihara S, Oyama S, Nishi M, Hamashima N
Division of Surgeruy, Cancer Institute Hospital.
Gan To Kagaku Ryoho. 1994 Aug;21(11):1800-5.
Six adjuvant chemotherapy protocols with 10 chemotherapy regimens were subjected to meta-analysis with an aim to clarify the survival benefits of adjuvant chemotherapy in gastric cancer. All adjuvant chemotherapies were compared with surgery alone, in cases from 1959 to 1982 in the Cancer Institute Hospital, Tokyo in the setting of controlled randomized study; and 1,177 gastric cancer patients with curative surgery were entered the studies. Pooled odds ratio and its 95% confidence interval was 0.63(0.51-0.78). The results suggested the survival benefits of adjuvant chemotherapy with mitomycin C and/or 5-fluorouracil in gastric cancer.
对六种包含10种化疗方案的辅助化疗方案进行了荟萃分析，目的是阐明辅助化疗对胃癌患者生存获益情况。在东京癌症研究所医院1959年至1982年开展的对照随机研究中，将所有辅助化疗与单纯手术进行比较；共有1177例接受根治性手术的胃癌患者纳入研究。合并比值比及其95%置信区间为0.63（0.51 - 0.78）。结果表明，丝裂霉素C和/或5-氟尿嘧啶辅助化疗对胃癌患者有生存获益。
