Wilkins A J, Jenkins W J, Steiner J A
Psychopharmacology (Berl). 1983;81(1):78-80. doi: 10.1007/BF00439278.
Clonidine hydrochloride 5 micrograms/kg and placebo were given orally to 11 patients experiencing well-developed alcohol withdrawal states. Active drug and placebo were given in a randomised, cross-over double blind fashion 2 h apart. Clonidine significantly suppressed heart rate (P = 0.002), arterial blood pressure (P = 0.006), and an accumulated score of withdrawal symptoms and signs (P = 0.004). These data suggest that clonidine may be useful in the management of alcohol withdrawal states, and that the underlying pathophysiology of at least some of these manifestations may be sympathetic nervous system hyperactivity.
对11例处于严重酒精戒断状态的患者口服5微克/千克的盐酸可乐定和安慰剂。活性药物和安慰剂以随机、交叉双盲的方式给药，间隔2小时。可乐定显著降低了心率（P = 0.002）、动脉血压（P = 0.006）以及戒断症状和体征的累积评分（P = 0.004）。这些数据表明，可乐定可能有助于治疗酒精戒断状态，并且至少其中一些表现的潜在病理生理学可能是交感神经系统功能亢进。
