Björkqvist S E
Acta Psychiatr Scand. 1975 Oct;52(4):256-63. doi: 10.1111/j.1600-0447.1975.tb00041.x.
In a doubl-blind study, patients receiving a rapidly falling dosage of clonidine recovered about 1 day faster from the symptoms of moderately severe alcohol withdrawal than patients receiving placebo. The effects of clonidine were especially noticeable with respect to tremor, sweating, elevated systolic blood pressure, tension, anxiety, depression, and general condition. Clonidine had no effect on the sleep disturbances. No significant side effects were seen. It is suggested that clonidine is a useful aid in the treatment of alcohol withdrawal, especially when it is desirable to minimise the use of tranquillisers.
在一项双盲研究中，与接受安慰剂的患者相比，接受快速递减剂量可乐定的患者从中度严重酒精戒断症状中恢复的时间快约1天。可乐定在震颤、出汗、收缩压升高、紧张、焦虑、抑郁和总体状况方面的效果尤为明显。可乐定对睡眠障碍没有影响。未观察到明显的副作用。有人认为可乐定在酒精戒断治疗中是一种有用的辅助药物，尤其是在希望尽量减少镇静剂使用的情况下。
