McIntyre I M, Kuhn C, Demitriou S, Fucek F R, Stanley M
Psychopharmacology (Berl). 1983;81(2):150-4. doi: 10.1007/BF00429010.
The effects of haloperidol, reserpine, and concomitant lithium were evaluated in biochemical, endocrine, and behavioral studies in the rat. Concomitant administration of a chronic regimen of haloperidol and lithium did not prevent the development of tolerance as noted by dopamine metabolites in the striatum or olfactory tuberculum. Nor did chronic lithium alter behavioral response in rats treated with reserpine and challenged with the dopamine agonist apomorphine. Additionally, prolactin release was increased by haloperidol, but was not altered by acute or chronic lithium treatment. These findings are discussed in the light of present knowledge of pre- and postsynaptic receptor changes and the effects of lithium.
在大鼠的生化、内分泌及行为学研究中评估了氟哌啶醇、利血平及锂盐联合使用的效果。如纹状体或嗅结节中的多巴胺代谢产物所示，长期联合使用氟哌啶醇和锂盐并不能阻止耐受性的产生。慢性锂盐也未改变用利血平处理并用多巴胺激动剂阿扑吗啡激发的大鼠的行为反应。此外，氟哌啶醇可使催乳素释放增加，但急性或慢性锂盐处理并未改变这种情况。根据目前关于突触前和突触后受体变化及锂盐作用的知识对这些发现进行了讨论。
