Rubin E H, Wooten G F
Psychopharmacology (Berl). 1984;84(2):217-20. doi: 10.1007/BF00427448.
Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute dopamine agonist administration and this effect of lithium summates with the behavioral augmentation caused by chronic amphetamine exposure. Although marked dopamine-related behavioral changes occur, chronic treatment with amphetamine, lithium, or both had no effect on levels of DA, DOPAC, HVA, and 3MT in either the striatum or nucleus accumbens. These results suggest that chronic amphetamine treatment with or without lithium does not affect presynaptic dopamine metabolism as assessed by metabolite levels. Furthermore, amphetamine-induced behavioral supersensitivity is not a simple function of changes in dopamine metabolism.
多巴胺能行为超敏反应可由长期使用多巴胺能激动剂或拮抗剂诱导产生。我们证明，激动剂诱导的超敏反应的发展对长期锂暴露具有抗性。此外，单独使用慢性锂可增强对急性多巴胺激动剂给药的刻板反应，并且锂的这种作用与慢性苯丙胺暴露引起的行为增强相加。尽管发生了明显的与多巴胺相关的行为变化，但长期使用苯丙胺、锂或两者对纹状体或伏隔核中的多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）、高香草酸（HVA）和3-甲氧基酪胺（3MT）水平均无影响。这些结果表明，无论有无锂，长期苯丙胺治疗均不影响通过代谢物水平评估的突触前多巴胺代谢。此外，苯丙胺诱导的行为超敏反应不是多巴胺代谢变化的简单函数。
