Chalon J, Martin P, Roberts C, Ramanathan S, Katz R, Turndorf H
Acta Anaesthesiol Scand. 1983 Oct;27(5):361-5. doi: 10.1111/j.1399-6576.1983.tb01968.x.
In order to assess the uptake of halothane by the goldfish, the respiratory rate of six fish was studied when water temperature was varied with and without changes in oxygen or carbon dioxide tension. The effective dose 50 of halothane (ED-50-H) and the time taken to reach it (T-ED-50-H) at an FIO2 of 0.35 in nitrogen, were studied when temperature and CO2 tension were varied. Nomograms were drawn to predict respiratory rate as a function of water CO2 tension, when CO2 was bubbled in air or in oxygen, and with changes in water temperature. At low temperatures (5 degrees C to 7.5 degrees C), respiratory rate remained below 10 per min, irrespective of CO2 partial pressure. At 28 degrees C, a CO2 partial pressure of 8 +/- 0.2 kPa produced a respiratory rate of 125 +/- 3/min in air, and in oxygen unexpectedly 140 +/- 3/min. Halothane ED-50 varied with temperature (0.8% at 10 degrees C and 1.6% at 23 degrees C). Time to reach ED-50-H decreased with increases in respiratory rate, but increased as water temperature was elevated.
为了评估金鱼对氟烷的摄取情况，研究了六条金鱼在水温变化且氧气或二氧化碳分压有无改变时的呼吸频率。在氮气中，当温度和二氧化碳分压变化时，研究了在吸入氧分数为0.35时氟烷的半数有效剂量（ED-50-H）及其达到该剂量所需的时间（T-ED-50-H）。绘制了列线图，以预测当二氧化碳通入空气或氧气中以及水温变化时，呼吸频率作为水二氧化碳分压的函数。在低温（5℃至7.5℃）下，无论二氧化碳分压如何，呼吸频率均保持在每分钟10次以下。在28℃时，8±0.2kPa的二氧化碳分压在空气中产生的呼吸频率为125±3次/分钟，而在氧气中出人意料地为140±3次/分钟。氟烷的ED-50随温度变化（10℃时为0.8%，23℃时为1.6%）。达到ED-50-H的时间随呼吸频率增加而减少，但随水温升高而增加。
