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[老年患者的瓣膜置换。风险及远期结果]

[Valve replacement in aged patients. Risk and remote results].

作者信息

Pelletier C, Martin-Albo C, Castonguay Y, Chaitman B R

出版信息

Arch Mal Coeur Vaiss. 1983 Sep;76(9):1039-46.

PMID:6416207
Abstract

A total of 102 patients aged 65 to 78 years underwent valvular replacement between 1975 and 1980. Calcific aortic stenosis was, by far, the commonest lesion (54 cases), followed by mitral stenosis (16 cases), mitral incompetence (14 cases), aortic incompetence (10 cases) and double valve lesions (8 cases). Sixty four patients underwent aortic valve replacement with 7 early deaths (10,9 p. 100). There were 30 mitral valve replacements with 7 deaths (23,3 p. 100) and 8 patients had double valve surgery with 4 deaths (50 p. 100). Aorto-coronary bypass grafting was associated in 25 cases with a 20 p. 100 mortality. Changes in the technique of peroperative myocardial protection have considerably reduced early mortality which has fallen from over 20 p. 100 to 2,9 p. 100 since the use of cardioplegia with local and systemic hypothermia. There was a higher surgical mortality in patients with poor left ventricular function, cardiomegaly and severe symptomatic incapacity. Non-fatal postoperative complications were common (50 p. 100 of survivors). There were 12 late deaths, 75 p. 100 of which were related to cardiovascular causes. The actuarial survival rate was 65,5 +/- 6 p. 100, 5 years after surgery. When operative mortality was excluded, the 5 year survival rate of the operated patients did not differ from that of the general populations of the same age (79,8 p. 100). Only 5 of our patients were lost to follow-up. Of the survivors, 95,5 p. 100 were asymptomatic or improved by at least one functional grade after an average postoperative period of 30 months. The incidence of late haemorrhagic complications in patients on anticoagulants was 11 p. 100.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1975年至1980年间,共有102名年龄在65岁至78岁之间的患者接受了瓣膜置换手术。到目前为止,钙化性主动脉瓣狭窄是最常见的病变(54例),其次是二尖瓣狭窄(16例)、二尖瓣关闭不全(14例)、主动脉瓣关闭不全(10例)和双瓣膜病变(8例)。64例患者接受了主动脉瓣置换术,7例早期死亡(10.9%)。30例患者接受了二尖瓣置换术,7例死亡(23.3%),8例患者接受了双瓣膜手术,4例死亡(50%)。25例患者接受了主动脉-冠状动脉旁路移植术,死亡率为20%。术中心肌保护技术的改变显著降低了早期死亡率,自采用局部和全身低温停搏液以来,早期死亡率已从超过20%降至2.9%。左心室功能差、心脏扩大和严重症状性功能不全的患者手术死亡率较高。非致命性术后并发症很常见(幸存者的50%)。有12例晚期死亡,其中75%与心血管原因有关。术后5年的精算生存率为65.5±6%。排除手术死亡率后,手术患者的5年生存率与同年龄普通人群的生存率无差异(79.8%)。我们的患者中只有5例失访。在幸存者中,平均术后30个月后,95.5%无症状或功能分级至少提高了一级。接受抗凝治疗的患者晚期出血并发症的发生率为11%。(摘要截断于250字)

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