Santoro S A
Biochem Biophys Res Commun. 1983 Oct 14;116(1):135-40. doi: 10.1016/0006-291x(83)90391-1.
Fibronectin is a large dimeric glycoprotein found in plasma, on cell surfaces and as a component of the extracellular matrix which has been implicated in a variety of adhesive processes. The role of fibronectin in platelet function has not been clarified. The present investigation demonstrates that an excess of exogenously added fibronectin inhibits platelet aggregation induced by either thrombin or A23187 at a step subsequent to platelet activation and secretion. Similar concentrations of fibrinogen or von Willebrand factor, both of which also bind to the surface of activated platelets, are not inhibitory. These results are consistent with the concept that fibronectin is one of the important mediators of platelet aggregation.
纤连蛋白是一种大型二聚体糖蛋白，存在于血浆、细胞表面，也是细胞外基质的组成成分，参与多种黏附过程。纤连蛋白在血小板功能中的作用尚未明确。本研究表明，外源性添加过量纤连蛋白会在血小板激活和分泌后的某个步骤抑制凝血酶或A23187诱导的血小板聚集。纤维蛋白原或血管性血友病因子的浓度与之相似，它们也都能结合到活化血小板表面，但并无抑制作用。这些结果与纤连蛋白是血小板聚集的重要介质之一这一概念相符。
