Jonzon A, Rondio Z, Sedin G
Br J Anaesth. 1983 Nov;55(11):1133-8. doi: 10.1093/bja/55.11.1133.
Pulmonary gas exchange was studied in association with high frequency ventilation and its relation to the duration of insufflation and end-expiratory pressure investigated. Alveolar deadspace, alveolar ventilation and the alveolar-arterial oxygen difference were obtained in cats receiving a constant minute ventilation. Alveolar deadspace increased with ventilatory frequency when a long insufflation time was used. A positive end-expiratory pressure (PEEP) decreased the alveolar deadspace in high frequency ventilation. Thus, with the low compressible volume ventilator, more efficient high frequency ventilation can be achieved with a short period of insufflation plus low PEEP.
研究了高频通气时的肺气体交换，并探讨了其与通气持续时间及呼气末压力的关系。在接受恒定分钟通气量的猫身上，测量了肺泡死腔、肺泡通气量和肺泡-动脉血氧分压差。当通气时间较长时，肺泡死腔随通气频率增加而增大。在高频通气时，呼气末正压（PEEP）可降低肺泡死腔。因此，使用低可压缩容积呼吸机，通过短时间通气加低PEEP可实现更有效的高频通气。
