Coward R A, Mallick N P, Delamore I W
Br Med J (Clin Res Ed). 1983 Nov 26;287(6405):1575-8. doi: 10.1136/bmj.287.6405.1575.
In a study of renal function in multiple myeloma seven patients presented with renal failure and three developed it 16-106 months after diagnosis. All were dialysed. Infection with dehydration was a precipitating factor in all seven cases of acute or acute on chronic renal failure. Of these, two patients recovered normal renal function and one other was left with permanent renal impairment but no longer required dialysis. Results from the seven patients with acute renal failure and for the three with more chronic features support the practice of dialysis for all patients who present with renal failure. Dialysis is not indicated for those patients with progressive myelomatous disease. The study showed no evidence that chemotherapy permitted recovery from established renal failure. The prognosis in this elderly group is heavily dependent on the presence of cardiovascular or other degenerative disease.
在一项关于多发性骨髓瘤肾功能的研究中，7例患者出现肾衰竭，3例在诊断后16 - 106个月出现肾衰竭。所有患者均接受透析治疗。感染合并脱水是所有7例急性或慢性肾衰竭急性发作病例的诱发因素。其中，2例患者肾功能恢复正常，另1例仍有永久性肾功能损害，但不再需要透析。7例急性肾衰竭患者和3例具有更多慢性特征患者的结果支持对所有出现肾衰竭的患者进行透析的做法。对于那些患有进行性骨髓瘤疾病的患者，不建议进行透析。该研究没有证据表明化疗能使已确立的肾衰竭恢复。这个老年群体的预后在很大程度上取决于是否存在心血管疾病或其他退行性疾病。
