Chan D W, Waud J M, Taylor E, Stem J, Drew H, Oropeza M, Sucupira M S
Clin Chem. 1983 Dec;29(12):2091-3.
Serum free thyroxin (FT4) was determined in 40 patients with various nonthyroidal illnesses. We studied seven methods: (1) a free thyroxin index calculated from total T4 and triiodothyronine resin uptake; (2) a free T4 index determined by enzyme inhibitor assays (Abbott's "Tetrazyme" and "Thyrozyme"); (3) a free T4 index calculated from total T4 and thyroxin-binding globulin; (4) free T4 by equilibrium dialysis; (5) Amersham's free T4 RIA; (6) Clinical Assays' one-step free T4 RIA; and (7) Clinical Assays' two-step free T4 RIA. Approximately half of the free T4 results were in the euthyroid range and the other half in the hypothyroid range by methods 1, 2, 5, and 6. Results for free T4 by methods 3 and 7 were similar to those by equilibrium dialysis (method 4), the percentages of patients with results in the euthyroid range being 68%, 65%, and 76%, respectively.
对40例患有各种非甲状腺疾病的患者测定了血清游离甲状腺素（FT4）。我们研究了七种方法：（1）根据总T4和三碘甲状腺原氨酸树脂摄取量计算的游离甲状腺素指数；（2）通过酶抑制剂测定法（雅培公司的“Tetrazyme”和“Thyrozyme”）测定的游离T4指数；（3）根据总T4和甲状腺素结合球蛋白计算的游离T4指数；（4）通过平衡透析法测定的游离T4；（5）阿美仙公司的游离T4放射免疫分析；（6）临床检测公司的一步法游离T4放射免疫分析；以及（7）临床检测公司的两步法游离T4放射免疫分析。通过方法1、2、5和6得出的游离T4结果中，约一半处于甲状腺功能正常范围，另一半处于甲状腺功能减退范围。方法3和7得出的游离T4结果与平衡透析法（方法4）的结果相似，甲状腺功能正常范围结果的患者百分比分别为68%、65%和76%。
