Adams M R, Rudel L L, Clarkson T B, Nelson C A, Thau R B, Moo-Young A J
Contraception. 1983 Sep;28(3):253-66. doi: 10.1016/0010-7824(83)90066-5.
The effect of a contraceptive vaginal ring (CVR) containing levonorgestrel on plasma lipid and lipoprotein concentrations and characteristics was assessed in ten cynomolgus monkeys. The animals were fed a diet similar to the average American diet in fat (40% of calories) and cholesterol (0.2 mg/kcal) content. The objective of this study was to determine if changes in lipids and lipoproteins caused by progestogen administration parallel those seen in human females. A parallel pattern would recommend the cynomolgus monkey as a model for studying the effects of progestogens on the atherosclerotic process. Treatment with the CVR resulted in significant decreases in total plasma, VLDL + ILDL + LDL, and HDL cholesterol concentrations and a decrease in the percentage of HDL2 in total HDL. Plasma triglyceride concentrations were low throughout the study and consistent effects of the CVR were not seen. CVR treatment resulted in increases in TPC:HDL-C ratios and in the flotation rate of the LDL particle. The patterns of effects on HDL cholesterol, total plasma cholesterol, and HDL2 concentrations were similar to the progestogen-induced changes observed in human plasma lipids and lipoproteins. Based on these effects, the cynomolgus monkey appears to be a suitable model for the study of progestogen-induced changes in plasma lipids and lipoproteins and their consequent influences on coronary artery atherosclerosis.
在十只食蟹猴中评估了含左炔诺孕酮的避孕阴道环（CVR）对血浆脂质和脂蛋白浓度及特性的影响。这些动物喂食的饮食在脂肪（占卡路里的40%）和胆固醇（0.2毫克/千卡）含量方面与美国平均饮食相似。本研究的目的是确定孕激素给药引起的脂质和脂蛋白变化是否与人类女性中观察到的变化相似。相似的模式将推荐食蟹猴作为研究孕激素对动脉粥样硬化进程影响的模型。用CVR治疗导致总血浆、极低密度脂蛋白+中间密度脂蛋白+低密度脂蛋白和高密度脂蛋白胆固醇浓度显著降低，以及高密度脂蛋白2在总高密度脂蛋白中的百分比降低。在整个研究过程中血浆甘油三酯浓度较低，未观察到CVR的一致作用。CVR治疗导致总血浆胆固醇与高密度脂蛋白胆固醇比值以及低密度脂蛋白颗粒的漂浮率增加。对高密度脂蛋白胆固醇、总血浆胆固醇和高密度脂蛋白2浓度的影响模式与在人类血浆脂质和脂蛋白中观察到的孕激素诱导的变化相似。基于这些作用，食蟹猴似乎是研究孕激素诱导的血浆脂质和脂蛋白变化及其对冠状动脉粥样硬化的后续影响的合适模型。
