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小鼠淋巴细胞在甲状腺上皮细胞单层上的同基因致敏。V. 初次同基因致敏受I-A亚区控制。

Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. V. The primary syngeneic sensitization is under I-A subregion control.

作者信息

Salamero J, Charreire J

出版信息

Eur J Immunol. 1983 Nov;13(11):948-51. doi: 10.1002/eji.1830131115.

DOI:10.1002/eji.1830131115
PMID:6416870
Abstract

The genetic control of in vitro primary syngeneic sensitization on monolayers of thyroid epithelial cells was investigated both at the level of the responder lymphocytes and that of stimulator thyroid epithelial cells using congenic resistant strains of mice. It clearly appears that similar to the in vivo model of experimental autoimmune thyroiditis induced by thyroglobulin and complete Freund's adjuvant, the optimal stimulation is found when compatibility between thyroid epithelial cells and responder lymphocytes occurs at the I-A subregion.

摘要

利用近交系抗性小鼠，在反应性淋巴细胞水平和刺激物甲状腺上皮细胞水平上，研究了甲状腺上皮细胞单层上体外原发性同基因致敏的遗传控制。显然，与由甲状腺球蛋白和完全弗氏佐剂诱导的实验性自身免疫性甲状腺炎的体内模型相似，当甲状腺上皮细胞与反应性淋巴细胞在I-A亚区具有相容性时，可发现最佳刺激效果。

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引用本文的文献

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H-2E(k) expression influences thyroiditis induction by the thyroglobulin peptide (2495-2511).H-2E(k)的表达会影响甲状腺球蛋白肽（2495-2511）诱导的甲状腺炎。
Immunogenetics. 1993;38(2):150-3. doi: 10.1007/BF00190903.
2
Interferon-gamma induces HLA-DR expression by thyroid epithelium.γ干扰素可诱导甲状腺上皮细胞表达HLA - DR。
Clin Exp Immunol. 1985 Aug;61(2):265-73.
3
HLA-D subregion expression by thyroid epithelium in autoimmune thyroid diseases and induced in vitro.自身免疫性甲状腺疾病中甲状腺上皮细胞的HLA - D亚区表达及体外诱导表达
Clin Exp Immunol. 1987 Sep;69(3):532-42.
4
Suppression of HLA class II expression on thyrocytes by interferon-alpha 1.α-干扰素对甲状腺细胞上HLA II类分子表达的抑制作用
Clin Exp Immunol. 1990 Mar;79(3):341-5. doi: 10.1111/j.1365-2249.1990.tb08093.x.
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Epidermal growth factor and transforming growth factor-alpha suppress HLA class II induction in human thyroid epithelial cells.表皮生长因子和转化生长因子-α抑制人甲状腺上皮细胞中II类组织相容性复合体的诱导表达。
Immunology. 1990 Jan;69(1):91-6.