Scholtes M C, Gerretsen G, Haak H L
Eur J Obstet Gynecol Reprod Biol. 1983 Oct;16(2):89-95. doi: 10.1016/0028-2243(83)90105-3.
The factor VIII ratio was measured in 102 pregnant women (43 uncomplicated pregnancies, 19 with pre-eclampsia without fetal growth retardation, 8 pre-eclampsia complicated by fetal growth retardation, 12 with only fetal growth retardation and 20 with gestational diabetes). The pathological pregnancies showed a statistically significant elevation of the factor VIII ratio compared to the normal pregnancies. The group of pre-eclampsia complicated by fetal growth retardation showed the most marked increase of the factor VIII ratio. The results are discussed in relation to the hypothesis that the elevated factor VIII ratio is mainly due to the release of factor VIII antigen by various forms of vascular stress.
对102名孕妇（43例无并发症妊娠、19例先兆子痫但无胎儿生长受限、8例先兆子痫合并胎儿生长受限、12例仅有胎儿生长受限和20例妊娠期糖尿病）测定了凝血因子VIII比率。与正常妊娠相比，病理性妊娠的凝血因子VIII比率有统计学意义的升高。先兆子痫合并胎儿生长受限组的凝血因子VIII比率升高最为明显。结合凝血因子VIII比率升高主要是由于各种形式的血管应激导致凝血因子VIII抗原释放这一假说对结果进行了讨论。
