放射性核素杂质的重要性及所需检测水平——医学物理学家的观点

The importance and required detection levels of radionuclide impurities--a medical physicist's view.

作者信息

Haggith J W

出版信息

Int J Nucl Med Biol. 1983;10(2-3):85-9. doi: 10.1016/0047-0740(83)90005-0.

Abstract

All radioactive impurities in radiopharmaceuticals contribute unnecessary radiation dose to the patient. gamma-Emitting impurities can adversely affect the quality of gamma-camera images and measurements of organ and sample radioactivity and can interfere with concurrent and subsequent nuclear medicine procedures. Full specification of radionuclidic content of all radiopharmaceuticals would help the user to avoid or minimise these effects. Detection levels of 1 in 10(6), and for alpha emitters 1 in 10(9), are required of suppliers and monitoring laboratories.

摘要

放射性药物中的所有放射性杂质都会给患者带来不必要的辐射剂量。发射γ射线的杂质会对γ相机图像的质量以及器官和样品放射性的测量产生不利影响，并且会干扰同时进行和后续的核医学程序。全面规定所有放射性药物的放射性核素含量将有助于使用者避免或尽量减少这些影响。供应商和监测实验室对放射性核素的检测水平要求为10⁶分之一，对于发射α粒子的核素则要求为10⁹分之一。