Banez E I, Triplett D A, Harms C S
Thromb Res. 1983 Sep 15;31(6):845-53. doi: 10.1016/0049-3848(83)90115-9.
A fluorogenic substrate assay of plasminogen was compared with acceptable methodologies, i.e., caseinolytic and radial immunodiffusion assays. Reference intervals based on a population of 25 members of the laboratory staff were 2.5-3.8 CTA u/ml (fluorogenic), 2.2-4.0 CTA u/ml (caseinolytic) and 8.7-14.3 mg/dl (RID). Ninety eight determinations were performed on 65 patients. Regression analysis showed linear correlation between the fluorometric and caseinolytic assays (r = 0.8046, p less than 0.03) and between the fluorometric and immunologic assays (r = 0.8572, p less than 0.005). Pre-operative and post-operative determinations were performed on 33 patients undergoing coronary artery bypass surgery and there was a consistent and significant (10%-76%) decrease in the plasminogen levels post-operatively (p less than 0.01). Twenty-five patients with various malignancies were compared with the normal population; no significant difference in the plasminogen levels was observed between the two groups.
对纤溶酶原的荧光底物测定法与可接受的方法进行了比较，即酪蛋白溶解测定法和放射免疫扩散测定法。基于25名实验室工作人员群体的参考区间为2.5 - 3.8 CTA单位/毫升（荧光法）、2.2 - 4.0 CTA单位/毫升（酪蛋白溶解法）和8.7 - 14.3毫克/分升（放射免疫扩散法）。对65例患者进行了98次测定。回归分析显示荧光测定法与酪蛋白溶解测定法之间呈线性相关（r = 0.8046，p < 0.03），荧光测定法与免疫测定法之间也呈线性相关（r = 0.8572，p < 0.005）。对33例接受冠状动脉搭桥手术的患者进行了术前和术后测定，术后纤溶酶原水平持续且显著降低（10% - 76%）（p < 0.01）。将25例患有各种恶性肿瘤的患者与正常人群进行比较；两组之间未观察到纤溶酶原水平有显著差异。
