Freiha F S, Faysal M H
Urology. 1983 Nov;22(5):496-8. doi: 10.1016/0090-4295(83)90227-3.
This report presents the results of 40 salvage cystectomies performed after failure of radiation therapy to control the disease in patients with bladder cancer. All patients had failure or recurrence after 7,000 rad. The time between end of radiation therapy and cystectomy was three to six months in 11 patients, seven to twelve months in 15, thirteen to twenty-four months in 8, and longer than thirty-six months in 6. There were two immediate and four late postoperative deaths. A total of twenty-two complications occurred in 16 patients. The five-year survival rate was 100 per cent for patients with in situ carcinoma, 58 per cent for Stage A disease, 50 per cent for Stage B1, and 40 per cent for Stage B2 disease. There were no survivors among patients with Stages C and D1 disease. Salvage cystectomy, although associated with significant morbidity, remains a viable form of therapy for patients in whom definitive radiotherapy fails.
本报告呈现了40例膀胱癌患者在放射治疗未能控制疾病后进行挽救性膀胱切除术的结果。所有患者在接受7000拉德照射后均出现治疗失败或复发。放射治疗结束至膀胱切除术的时间间隔为：11例患者为三至六个月，15例为七至十二个月，8例为十三至二十四个月，6例超过三十六个月。术后有2例即刻死亡和4例晚期死亡。16例患者共出现22种并发症。原位癌患者的五年生存率为100%，A期疾病患者为58%，B1期为50%，B2期为40%。C期和D1期疾病患者无存活者。挽救性膀胱切除术尽管伴有显著的发病率，但对于明确放疗失败的患者而言仍是一种可行的治疗方式。
