Meydani S N, Nicolosi R J, Sehgal P K, Hayes K C
Am J Clin Nutr. 1983 Dec;38(6):888-94. doi: 10.1093/ajcn/38.6.888.
Certain owl monkeys (AOT) develop spontaneous hemolytic anemia that responds to vitamin E. The anemia is associated with red blood cell lipid peroxidation and altered red blood cell membrane lipid composition. To investigate these changes, plasma lipid and lipoprotein profiles were characterized in anemic, anemia-susceptible, and anemia-resistant AOT. The plasma vitamin E and vitamin A concentrations were assessed as an index of fat absorption and the effect of corn oil supplementation and vitamin E-selenium injection were measured. Anemia-susceptible AOT had depressed plasma levels of vitamin E and A and an altered lipoprotein metabolism characterized by elevated ratios of low/high density lipoprotein cholesterol and free to esterified cholesterol in these lipoproteins. Vitamin E-selenium injection in anemia-susceptible AOT increased the plasma vitamin E, and vitamin E and corn oil supplements reduced the high density lipoprotein free to esterified cholesterol ratio. The data suggest that the AOT suffer from fat malabsorption and that the consequences (including tocopherol deficiency) result in altered cholesterol metabolism.
某些夜猴（AOT）会患上自发性溶血性贫血，而维生素E对其有疗效。这种贫血与红细胞脂质过氧化以及红细胞膜脂质组成的改变有关。为了研究这些变化，对贫血、易患贫血和抗贫血的AOT的血浆脂质和脂蛋白谱进行了表征。评估了血浆维生素E和维生素A浓度作为脂肪吸收的指标，并测量了补充玉米油和注射维生素E-硒的效果。易患贫血的AOT血浆中维生素E和A水平降低，脂蛋白代谢发生改变，其特征是这些脂蛋白中低密度/高密度脂蛋白胆固醇以及游离胆固醇与酯化胆固醇的比率升高。对易患贫血的AOT注射维生素E-硒可提高血浆维生素E水平，补充维生素E和玉米油可降低高密度脂蛋白中游离胆固醇与酯化胆固醇的比率。数据表明，AOT存在脂肪吸收不良的问题，其后果（包括生育酚缺乏）导致胆固醇代谢改变。
