高效液相色谱法测定软膏剂和混悬剂中环己酰亚胺的含量
High-pressure liquid chromatographic determination of cycloheximide in ointment and suspension formulations.
作者信息
Brown L W
出版信息
J Pharm Sci. 1978 May;67(5):669-72. doi: 10.1002/jps.2600670526.
A high-pressure liquid chromatographic procedure is described for the assay of the antibiotic cycloheximidein bulk drug and two experimental formulations. The method utilizes a reversed-phase C18 chromatographic column and refractive index detection. Possible impurities or degradation products, isocycloheximide, anhydrocycloheximide, and dimethylcyclohexone, are well separated from cycloheximide by this procedure. Complete extraction of cycloheximide from the formulations was obtained. The assay has a relative standard deviation of approximately 1%.
描述了一种高压液相色谱法，用于测定原料药和两种实验制剂中的抗生素放线菌酮。该方法采用反相C18色谱柱和折光率检测。通过该方法，放线菌酮的可能杂质或降解产物异放线菌酮、脱水放线菌酮和二甲基环己酮能与放线菌酮良好分离。从制剂中完全提取出了放线菌酮。该测定法的相对标准偏差约为1%。
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