Brown L W
J Pharm Sci. 1978 Sep;67(9):1254-7. doi: 10.1002/jps.2600670917.
High-pressure liquid chromatographic procedures are described for clindamycin, clindamycin palmitate, and clindamycin phosphate as bulk drugs and in formulations. All three procedures utilize a C18 reversed-phase chromatographic column with refractive index detection. The mobile phases are hydroalcoholic solutions containing dioctyl sodium sulfosuccinate or disodium ethylenediaminetetraacetate. Separations of related impurities or degradation products also are discussed. The relative standard deviations of the methods range from 0.8 to 1.8%.
描述了用于克林霉素、克林霉素棕榈酸酯和克林霉素磷酸酯原料药及制剂的高压液相色谱法。所有这三种方法都使用带折光率检测的C18反相色谱柱。流动相是含有磺基琥珀酸二辛酯钠或乙二胺四乙酸二钠的水醇溶液。还讨论了相关杂质或降解产物的分离情况。这些方法的相对标准偏差范围为0.8%至1.8%。
