关于酮替芬对豚鼠回肠作用的进一步研究。

Further studies on the effects of ketotifen on guinea pig ileum.

作者信息

Alvarez R G, Arruzazabala M L

出版信息

Arch Immunol Ther Exp (Warsz). 1983;31(3):401-7.

Abstract

Ketotifen (Ke) at the concentration of 10(-5) M or greater significantly inhibits guinea pig ileum contractions induced by cumulative dose response curves to Pg alpha F2 or BaCl2. This inhibitory effect of Ke is also observable against ileal contractions induced by isotonic and hypertonic solutions with high K+ and by electrical stimulation. In contrast to the long term antihistaminic effect of DSCG and Ke, the latter drug exhibits a shorter inhibitory effect when Ach and electrical stimulation are used to induce ileal contractions shortly after Ke is removed by washing from the organ bath. This nonspecific protective effect of Ke on smooth muscle against various spasmogens resembles the one reported recently by us for DSCG and might be relevant to the antiallergic and antiasthmatic properties of both drugs.

摘要

浓度为10⁻⁵M或更高的酮替芬（Ke）能显著抑制豚鼠回肠由PgαF2或BaCl₂累积剂量反应曲线诱导的收缩。Ke的这种抑制作用在对抗由高钾等渗和高渗溶液以及电刺激诱导的回肠收缩时也可观察到。与色甘酸钠（DSCG）和Ke的长期抗组胺作用不同，当通过从器官浴中冲洗去除Ke后不久，使用乙酰胆碱（Ach）和电刺激诱导回肠收缩时，后一种药物表现出较短的抑制作用。Ke对平滑肌针对各种致痉剂的这种非特异性保护作用类似于我们最近报道的DSCG的作用，可能与这两种药物的抗过敏和抗哮喘特性有关。