酮替芬对豚鼠气管的保护作用。

Protective effects of ketotifen on guinea pig trachea.

作者信息

de Lourdes Arruzazabala M, González Alvarez R

出版信息

Respiration. 1984;45(1):50-5. doi: 10.1159/000194597.

DOI:10.1159/000194597

Abstract

We have studied the effects of ketotifen (Ke), an effective antiallergic drug, on guinea pig trachea. Ke (10(-6)-5 X 10(-5) M) inhibits contractions induced in this preparation by acetylcholine, prostaglandin F2 alpha, barium chloride, potassium chloride and electrical stimulation. These results provide evidence for protective effects of Ke in airways. Furthermore, Ke exerts also a neural inhibitory effect on postganglionic parasympathetic fibers of guinea pig trachea. These findings resemble the effects reported previously for disodium cromoglycate by us and might be relevant for antiasthmatic and antiallergic properties of Ke.

摘要

我们研究了有效抗过敏药物酮替芬（Ke）对豚鼠气管的作用。Ke（10⁻⁶ - 5×10⁻⁵ M）可抑制该制剂中由乙酰胆碱、前列腺素F2α、氯化钡、氯化钾和电刺激诱导的收缩。这些结果为Ke在气道中的保护作用提供了证据。此外，Ke对豚鼠气管的节后副交感神经纤维也有神经抑制作用。这些发现与我们之前报道的色甘酸钠的作用相似，可能与Ke的抗哮喘和抗过敏特性有关。