Kuller L H, Radford E P
Environ Health Perspect. 1983 Oct;52:131-9. doi: 10.1289/ehp.8352131.
Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effects, but studies in human subjects with compromised coronary or peripheral circulation support an effect of acute exposure to CO at blood levels equivalent to about 20 ppm over several hours. It is possible that some of the cardiovascular effects of smoking may be related to the high levels of CO in cigarette smoke, but it has been difficult to isolate the contribution of CO independent of the effects of other smoke constituents.
一氧化碳在环境中广泛分布，其急性或慢性毒性作用可能具有相当大的公共卫生意义。本文对当前环境标准的依据进行了综述。关于一氧化碳水平与健康影响之间的关系，死亡率和发病率研究结果呈阴性或不明确，但对冠状动脉或外周循环受损的人体受试者的研究表明，在数小时内血液中一氧化碳水平相当于约20 ppm时，急性接触一氧化碳会产生影响。吸烟的一些心血管影响可能与香烟烟雾中高水平的一氧化碳有关，但很难将一氧化碳的作用与其他烟雾成分的影响区分开来。
