慢性非甲非乙型肝炎中循环免疫复合物的特征分析

Characterization of circulating immune complexes in chronic non-A, non-B hepatitis.

作者信息

Poralla T, Hütteroth T H, Arnold W, Dienes H P, Meyer zum Büschenfelde K H

出版信息

Digestion. 1983;28(2):90-5. doi: 10.1159/000198969.

DOI:10.1159/000198969

Abstract

We studied the frequency and composition of circulating immune complexes (CIC) in patients with chronic persistent non-A, non-B (NANB) hepatitis and in convalescent persons after an apparently normal recovery from acute NANB hepatitis. 10 of 16 patients with chronic NANB hepatitis and 5 of 11 convalescent persons after acute NANB hepatitis had CIC as detected by the Raji cell technique. CIC in chronic NANB hepatitis were composed of IgG, C3, and in 7 of 10 cases also IgM, while in CIC from convalescent persons IgG and C3 were present, too, but IgM was detected in only 1 case. Viral antigens within the CIC were not detectable in any case while 14 of 16 chronic NANB hepatitis patients were found to have free virus-associated antigen in serum.

摘要

我们研究了慢性持续性非甲非乙型（NANB）肝炎患者以及急性NANB肝炎明显正常恢复后的康复者体内循环免疫复合物（CIC）的频率和组成。采用Raji细胞技术检测发现，16例慢性NANB肝炎患者中有10例、11例急性NANB肝炎康复者中有5例存在CIC。慢性NANB肝炎中的CIC由IgG、C3组成，10例中有7例还含有IgM，而康复者的CIC中也存在IgG和C3，但仅1例检测到IgM。在任何情况下，CIC内均未检测到病毒抗原，而16例慢性NANB肝炎患者中有14例血清中存在游离的病毒相关抗原。