Jensen J R, Sand T T, Jørgensen A S, Thestrup-Pedersen K
J Invest Dermatol. 1984 Jan;82(1):30-4. doi: 10.1111/1523-1747.ep12259055.
The peripheral blood lymphocytes of 36 adult patients with moderate to severe atopic dermatitis had reduced natural killer (NK) cell activity when measured against 51Cr-labeled K 562 cells. The decrease in NK cells activity was not related to the serum IgE level, but was related to the severity of the skin disease. Addition of autologous monocytes of the assay reduced the NK cell activity and concealed the enhancing effect of gamma-interferon addition in a 4-h assay. The NK cell activity of lymphocytes could be reduced in vitro by addition of prostaglandin E1, or increased by addition of gamma-interferon similar to lymphocytes from persons without atopic disease. Our present findings raise the possibility that the reduced NK cell activity may be secondary to the skin disease, and due to in vivo interaction between NK cells and monocytes, or to low numbers of NK cells in peripheral blood.
36例中重度特应性皮炎成年患者的外周血淋巴细胞在检测针对51Cr标记的K562细胞时，其自然杀伤（NK）细胞活性降低。NK细胞活性的降低与血清IgE水平无关，但与皮肤病的严重程度有关。在检测中加入自体单核细胞会降低NK细胞活性，并在4小时的检测中掩盖加入γ干扰素的增强作用。与无特应性疾病者的淋巴细胞一样，加入前列腺素E1可在体外降低淋巴细胞的NK细胞活性，加入γ干扰素则可使其增加。我们目前的研究结果提示，NK细胞活性降低可能继发于皮肤病，是由于NK细胞与单核细胞在体内的相互作用，或外周血中NK细胞数量较少所致。
