Ternowitz T, Herlin T
Arch Dermatol Res. 1986;278(6):454-9. doi: 10.1007/BF00455163.
Using highly purified cell suspensions, monocyte (MO) and polymorphonuclear leukocyte (PMN) chemotaxis was measured by the 51Cr-labeled cells technique in 30 adult patients with atopic dermatitis (AD). MO chemotaxis was depressed in 60% of the patients; in one-third both MO and PMN chemotaxis was impaired. All patients with normal MO chemotaxis had normal PMN chemotaxis. The defective chemotaxis was related to the presence of cutaneous infection and to the activity of the disease. Cutaneous infection was observed in 70% of the patients with low MO and PMN chemotaxis. We found no relation between the chemotaxis defects and serum IgE levels. Presence of asthma in addition to AD did not influence the results. Preincubation of normal leukocytes with AD plasma did not alter the chemotactic responses. Plasma from atopics had a lower capacity for inducing migration than normal plasma using leukocytes from healthy subjects as test cells.
采用高度纯化的细胞悬液，运用51Cr标记细胞技术，对30例成年特应性皮炎（AD）患者的单核细胞（MO）和多形核白细胞（PMN）趋化性进行了检测。60%的患者MO趋化性降低；三分之一的患者MO和PMN趋化性均受损。所有MO趋化性正常的患者PMN趋化性也正常。趋化性缺陷与皮肤感染的存在以及疾病的活动度有关。在MO和PMN趋化性低的患者中，70%观察到皮肤感染。我们发现趋化性缺陷与血清IgE水平之间无关联。除AD外还患有哮喘并不影响结果。用AD血浆预孵育正常白细胞不会改变趋化反应。以健康受试者的白细胞作为测试细胞时，特应性个体的血浆诱导迁移的能力低于正常血浆。
