Doose H, Sitepu B
Neuropediatrics. 1983 Nov;14(4):220-4. doi: 10.1055/s-2008-1059582.
The incidence of epilepsy in children between 0 up to 8 years in the city of Kiel in Northern Germany was calculated. The study is based on a case documentation of the Kiel Epilepsy Center from 1957 to 1975. In this period 235 children were registered who were born in the years 1957 to 1966 and suffered from a single or recurrent epileptic seizures prior to their 9th birthday. Based upon the 37 691 children born in Kiel in the years 1957 to 1966, the mean cumulative risk for a single or recurrent epileptic seizures through the age of 8 is 6.23% (7.27% for boys, 5.12% for girls). Sixty percent of the children had their first seizure prior to the third birthday. The incidence rate for children below the age of 9 was 71.9/100.000 in 1965 and 72.4/100.000 in 1966. The maximum incidence rate was found in the first year of life (201.6).--The prevalence could only be estimated by summation of the cumulative incidence and was 4.5% in 1965. The clinical symptomatology was dominated by grand mal (68%), followed by partial seizures with complex (17%) and elementary symptomatology (16%), nonconvulsive generalized seizures (13%), infantile spasms (8%). Remarkably frequent is the benign epilepsy with centro-temporal sharp waves comprising 8% of the total group.
计算了德国北部基尔市0至8岁儿童的癫痫发病率。该研究基于基尔癫痫中心1957年至1975年的病例记录。在此期间，登记了235名儿童，他们出生于1957年至1966年，在9岁生日前患有单次或复发性癫痫发作。根据1957年至1966年在基尔出生的37691名儿童，8岁前单次或复发性癫痫发作的平均累积风险为6.23%（男孩为7.27%，女孩为5.12%）。60%的儿童在3岁生日前首次发作。1965年9岁以下儿童的发病率为71.9/100000，1966年为72.4/100000。发病率最高的是出生后第一年（201.6）。——患病率只能通过累积发病率相加来估计，1965年为4.5%。临床症状以大发作为主（68%），其次是复杂部分性发作（17%）和基本症状发作（16%）、非惊厥性全身性发作（13%）、婴儿痉挛症（8%）。显著常见的是中央颞区尖波的良性癫痫，占总病例组的8%。
