Ishihara Y, Kitamura S, Takaku F
Prostaglandins. 1983 Oct;26(4):623-9. doi: 10.1016/0090-6980(83)90199-5.
Male Hartley strain guinea pigs weighing about 200g were used as the experimental animals. Histamine and SRS-A released from the lung tissue were measured by the bioassay methods. The amount of histamine released from passively sensitized lung tissue by the challenge of antigen showed marked decrease by preincubating with AA-861 or T-22083, and the percentage inhibition by AA-861 was greater than that by T-22083. The amount of SRS-A released from sensitized lung tissue by the challenge with antigen showed marked decrease by preincubation with AA-861 or T-22083, and the percentage inhibition by AA-861 was greater than that by T-22083. The above results suggest that AA-861 and T-22083 have not only an inhibitory action on the release of SRS-A from sensitized lung tissue but also have an inhibitory action on the release of histamine.
体重约200克的雄性Hartley品系豚鼠用作实验动物。通过生物测定法测量从肺组织释放的组胺和慢反应物质A（SRS - A）。用抗原激发被动致敏的肺组织释放的组胺量，通过与AA - 861或T - 22083预孵育显示出显著降低，并且AA - 861的抑制百分比大于T - 22083。用抗原激发致敏肺组织释放的SRS - A量，通过与AA - 861或T - 22083预孵育显示出显著降低，并且AA - 861的抑制百分比大于T - 22083。上述结果表明，AA - 861和T - 22083不仅对致敏肺组织释放SRS - A有抑制作用，而且对组胺释放也有抑制作用。
