Toledo-Pereyra L H, Gordon D A, MacKenzie G H
Surg Gynecol Obstet. 1984 Jan;158(1):49-56.
In an effort to improve the viability of canine pancreatic islet cell allografts after cryopreservation, Cy A was used for graft pretreatment and as a general immunosuppressant on graft recipients who had previously undergone pancreatectomy. Using this combination in conjunction with cryopreservation, islet cell allografts exhibited good viability and long term function after freezing to minus 196 degrees C. These results might encourage the further use of this technique for transplantation.
为提高犬胰岛细胞同种异体移植冷冻保存后的存活率，环孢素A（Cy A）被用于移植物预处理，并作为一种常规免疫抑制剂用于先前已接受胰腺切除术的移植物受体。将这种联合方法与冷冻保存相结合，胰岛细胞同种异体移植在冷冻至零下196摄氏度后表现出良好的存活率和长期功能。这些结果可能会促使该技术在移植中得到进一步应用。
