Zemlan F P, Hirschowitz J, Sautter F J, Garver D L
Br J Psychiatry. 1984 Jan;144:64-9. doi: 10.1192/bjp.144.1.64.
The authors have previously reported that a sub-group of schizophrenic-like patients respond favorably to lithium therapy: furthermore, psychotic patients who respond to lithium demonstrate appreciable improvement during the first seven days of treatment. The present study investigated which symptoms of schizophrenia improved quickly during lithium treatment. We found that patients who do respond to lithium show significant improvement in the core symptoms of psychosis--hallucinations, delusions and formal thought disorder--during the first seven days of treatment, thus allowing early identification of 88 per cent of schizophrenic patients who ultimately respond to lithium and 91 per cent of those who do not.
作者此前曾报道，有一类精神分裂症样患者对锂盐治疗反应良好：此外，对锂盐有反应的精神病患者在治疗的前七天内症状有明显改善。本研究调查了锂盐治疗期间精神分裂症的哪些症状改善迅速。我们发现，对锂盐有反应的患者在治疗的前七天内，精神病的核心症状——幻觉、妄想和形式思维障碍——有显著改善，从而能够早期识别出最终对锂盐有反应的88%的精神分裂症患者以及91%无反应的患者。
