Jowett N I, Williams L G, Hitman G A, Galton D J
Br Med J (Clin Res Ed). 1984 Jan 14;288(6411):96-9. doi: 10.1136/bmj.288.6411.96.
A polymorphic DNA sequence was studied on the 5' flanking region of the human insulin gene in relation to diabetic lipaemia. The genotype frequencies in a control population (n = 52) were homozygous L 6%, heterozygous 54%, and homozygous S 40%. Corresponding genotype frequencies in a hypertriglyceridaemic group (n = 74) were 18%, 66%, and 16% (p less than 0.01; chi 2 test). When the hypertriglyceridaemic patients were divided on the basis of glucose tolerance the corresponding genotype frequencies in the diabetic subgroup (n = 23) were 39%, 52%, and 9% compared with 0%, 74%, and 26% in the non-diabetics (n = 34) (p less than 0.001; chi 2 test). These findings suggest that the homozygous L genotype may confer susceptibility to diabetic hypertriglyceridaemia.
对人类胰岛素基因5'侧翼区的一个多态性DNA序列与糖尿病性脂血症的关系进行了研究。对照组人群（n = 52）的基因型频率为：纯合子L型6%，杂合子54%，纯合子S型40%。高甘油三酯血症组（n = 74）相应的基因型频率为18%、66%和16%（p<0.01；卡方检验）。当根据葡萄糖耐量对高甘油三酯血症患者进行分组时，糖尿病亚组（n = 23）相应的基因型频率为39%、52%和9%，而非糖尿病组（n = 34）为0%、74%和26%（p<0.001；卡方检验）。这些发现提示纯合子L基因型可能使个体易患糖尿病性高甘油三酯血症。
