Lister R G, Greenblatt D J, Abernethy D R, File S E
Brain Res. 1984 Jan 2;290(1):183-6. doi: 10.1016/0006-8993(84)90752-2.
Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.
利用带氮磷检测的气相色谱法以及反相高效液相色谱法，开发了测定脑组织中Ro 15 - 1788的方法。将这些方法应用于大鼠的药代动力学研究发现，Ro 15 - 1788从大鼠脑中消除的半衰期为16分钟。在所研究的时间点，大鼠血浆中未检测到Ro 15 - 1788。如果同时给予氯氮卓，脑中Ro 15 - 1788的浓度会降低。
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