Salvin S B, Tanner E P
Clin Exp Immunol. 1984 Jan;55(1):133-9.
Three parameters of cell-mediated immunity, namely, (a) resistance to infection with Candida albicans, (b) in vivo release of migration inhibitory factor (MIF) into the circulation and (c) delayed hypersensitivity were markedly reduced when mice of such normally resistant high responder strains as C57B1/10SNJ and C57B1/KsJ became hyperglycaemic after treatment with alloxan. When the alloxan diabetic mice were inoculated daily intraperitoneally with thymosin fraction 5, beginning 3 days before infection, resistance to infection was greatly enhanced. When the mice were administered 5 micrograms thymosin fraction 5 for 3 days before sensitization and for 3 days before challenge, the amount of MIF released in vivo into the circulation after the antigenic challenge was much greater. When the mice were treated daily with 5 micrograms thymosin fraction 5, beginning on the day of sensitization, the capacity to develop delayed footpad reactions was increased. Thus, the treatment of alloxan diabetic mice with thymosin fraction 5 enhanced the three parameters of cell-mediated immunity that were under investigation.
当正常具有抗性的高反应性品系小鼠，如C57B1/10SNJ和C57B1/KsJ，用四氧嘧啶处理后出现高血糖时，细胞介导免疫的三个参数，即：（a）对白色念珠菌感染的抵抗力，（b）体内迁移抑制因子（MIF）释放到循环系统中，以及（c）迟发型超敏反应，均显著降低。当从感染前3天开始，每天给四氧嘧啶糖尿病小鼠腹腔注射胸腺素5组分时，对感染的抵抗力大大增强。当在致敏前3天和攻击前3天给小鼠施用5微克胸腺素5组分时，抗原攻击后体内释放到循环系统中的MIF量要大得多。当从致敏当天开始，每天用5微克胸腺素5组分处理小鼠时，产生迟发型足垫反应的能力增强。因此，用胸腺素5组分治疗四氧嘧啶糖尿病小鼠增强了所研究的细胞介导免疫的三个参数。
