Letendre P W, Barr C, Wilkens K
Drug Intell Clin Pharm. 1984 Jan;18(1):69-70. doi: 10.1177/106002808401800113.
The incidence of adverse effects from transdermal nitroglycerin systems is reported to be very low. A cutaneous reaction from Transderm-Nitro is described. The patient in this case was a 63-year-old male with a history of chronic obstructive lung disease, adult onset diabetes mellitus, peptic ulcer disease, congestive heart failure, and angina pectoris. Seven weeks after having used a Transderm-Nitro-5 patch daily, the patient was found to have two macular erythematous areas on his chest that corresponded to the exact sites of the nitroglycerin patch. Follow-up with the same patient, using a placebo Transderm-Nitro, elicited a reaction similar in appearance. The exact causative agent is unknown, but it is believed to be from the transdermal delivery system and not the nitroglycerin.
据报道，经皮硝酸甘油系统的不良反应发生率非常低。本文描述了一例使用硝酸甘油透皮贴剂（Transderm-Nitro）引起的皮肤反应。该患者为63岁男性，有慢性阻塞性肺疾病、成年型糖尿病、消化性溃疡病、充血性心力衰竭和心绞痛病史。在每天使用硝酸甘油透皮贴剂（Transderm-Nitro-5）七周后，发现患者胸部有两个斑疹样红斑区域，与硝酸甘油贴剂的精确位置相对应。对该患者使用安慰剂硝酸甘油透皮贴剂进行随访，出现了外观相似的反应。确切的致病因素尚不清楚，但据信是来自经皮给药系统而非硝酸甘油。
