Schenken R S, Asch R H, Williams R F, Hodgen G D
Fertil Steril. 1984 Jan;41(1):122-30. doi: 10.1016/s0015-0282(16)47552-7.
To elucidate the etiology of infertility due to endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum of 21 cynomolgus monkeys. These primates were divided into five groups: control animals with adipose tissue autografts (n = 5), animals with microscopic endometriosis (n = 5), animals with mild endometriosis (n = 5), animals with moderate endometriosis (n = 4), and animals with severe endometriosis (n = 2). During three subsequent menstrual cycles, each animal underwent (1) serial assay of peripheral serum gonadotropins and steroids; (2) mating timed according to daily serum 17 beta-estradiol; and (3) laparotomy to document an ovulatory stigma. The chemical and term pregnancy rates were lower among monkeys with moderate or severe endometriosis, as compared with control animals. The impaired fertility in monkeys with endometriosis appeared to be mediated primarily by failure of follicular rupture and/or pelvic adhesions.
为阐明子宫内膜异位症所致不孕的病因，我们将子宫内膜或脂肪组织自体移植到21只食蟹猴的盆腔腹膜。这些灵长类动物被分为五组：脂肪组织自体移植的对照动物（n = 5）、显微镜下子宫内膜异位症动物（n = 5）、轻度子宫内膜异位症动物（n = 5）、中度子宫内膜异位症动物（n = 4）和重度子宫内膜异位症动物（n = 2）。在随后的三个月经周期中，每只动物均接受：（1）外周血清促性腺激素和类固醇的系列测定；（2）根据每日血清17β-雌二醇安排交配时间；（3）剖腹手术以记录排卵点。与对照动物相比，中度或重度子宫内膜异位症猴子的化学妊娠率和足月妊娠率较低。子宫内膜异位症猴子的生育力受损似乎主要是由卵泡破裂失败和/或盆腔粘连介导的。
