Zumoff B, Strain G W, Kream J, Levin J, Fukushima D K
J Reprod Med. 1983 Dec;28(12):843-6.
The 24-hour mean plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured during the follicular phase of the menstrual cycle in 15 healthy, regularly cycling obese women (59-218% above desirable weight) and 9 healthy, regularly cycling nonobese women (14% below to 14% above desirable weight). The obese women showed slightly but not significantly higher FSH values (12.5 vs. 9.6 mIU/ml), definitely and significantly lower LH values (11 vs. 17 mIU/ml; p less than 0.005) and markedly and very significantly higher FSH/LH ratios (1.2 vs. 0.62; p less than 0.0005). These abnormalities may represent a human counterpart of the slow-GnRH-pulsing model of primates: monkeys in which the GnRH secretory centers have been ablated and that receive GnRH infusions at subnormal pulsing rates show slightly elevated FSH levels, markedly decreased LH levels, greatly elevated FSH/LH ratios and anovulation.
在月经周期的卵泡期，对15名健康、月经周期规律的肥胖女性（体重比理想体重高59%-218%）和9名健康、月经周期规律的非肥胖女性（体重比理想体重低14%至高14%）测定了促黄体生成素（LH）和促卵泡生成素（FSH）的24小时平均血浆浓度。肥胖女性的FSH值略高但无显著差异（12.5对9.6 mIU/ml），LH值明显且显著降低（11对17 mIU/ml；p<0.005），FSH/LH比值显著且非常显著升高（1.2对0.62；p<0.0005）。这些异常可能是灵长类动物慢GnRH脉冲模型在人类中的对应表现：切除GnRH分泌中心并以低于正常脉冲频率接受GnRH输注的猴子，其FSH水平略有升高，LH水平显著降低，FSH/LH比值大幅升高且无排卵。
