Turski L, Havemann U, Kuschinsky K
Life Sci. 1983;33 Suppl 1:755-8. doi: 10.1016/0024-3205(83)90612-4.
The effects of the benzodiazepines diazepam and midazolam on the rigidity produced by systemic administration of morphine (15 mg/kg i.p.) were studied in rats. The rigidity was recorded as a tonic activity from the gastrocnemius-soleus muscle of non-anesthetized rats in the electromyogram. Both diazepam (1-5 mg/kg i.p.) and midazolam (2.5 and 5 mg/kg i.p.), when administered 45 min after morphine, temporarily antagonized the muscular rigidity. When the competitive antagonist Ro 15-1788 (ethyl-8-fluoro-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4]benzodiazepine-3 -carboxylate) (5 mg/kg i.p.) was administered together with diazepam (5 mg/kg i.p.), it prevented the effect of diazepam, although by itself it did not affect the morphine-induced muscular rigidity. Our results suggest that diazepam, by acting on benzodiazepine receptors, can antagonize the morphine-induced muscular rigidity. The latter phenomenon might serve as a model for some types of muscular rigidity observed in humans.
研究了苯二氮䓬类药物地西泮和咪达唑仑对大鼠腹腔注射吗啡（15毫克/千克）所致强直的影响。强直表现为非麻醉大鼠腓肠肌-比目鱼肌在肌电图中的强直活动。吗啡注射45分钟后，腹腔注射地西泮（1-5毫克/千克）和咪达唑仑（2.5和5毫克/千克）均可暂时拮抗肌肉强直。当竞争性拮抗剂Ro 15-1788（8-氟-5,6-二氢-5-甲基-6-氧代-4H-咪唑并[1,5a][1,4]苯二氮䓬-3-羧酸乙酯）（5毫克/千克腹腔注射）与地西泮（5毫克/千克腹腔注射）一起给药时，可阻断地西泮的作用，尽管其本身并不影响吗啡诱导的肌肉强直。我们的结果表明，地西泮通过作用于苯二氮䓬受体，可拮抗吗啡诱导的肌肉强直。后一种现象可能是人类某些类型肌肉强直的模型。
