Schwarz M, Turski L, Sontag K H
Eur J Pharmacol. 1983 May 20;90(1):139-42. doi: 10.1016/0014-2999(83)90226-1.
The muscle relaxant effects of diazepam and progabide were studied in mutant Han-Wistar rats which exhibit spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Treatment with diazepam or progabide produced a dose-related reduction of the spontaneous activity measured in the electromyogram. The depressant effect of diazepam, but not that of progabide was antagonized by the specific benzodiazepine antagonist Ro 15-1788. From these data it is apparent that the muscle relaxant effect of progabide is not mediated through an alteration of benzodiazepine receptors.
在突变的Han-Wistar大鼠中研究了地西泮和普罗加比的肌肉松弛作用，这些大鼠在腓肠肌-比目鱼肌的肌电图中表现出自发性强直活动。用地西泮或普罗加比治疗可使肌电图中测得的自发活动呈剂量依赖性降低。特异性苯二氮䓬拮抗剂Ro 15-1788可拮抗地西泮的抑制作用，但不能拮抗普罗加比的抑制作用。从这些数据可以明显看出，普罗加比的肌肉松弛作用不是通过改变苯二氮䓬受体介导的。
