Check J H, Adelson H G
Obstet Gynecol. 1984 Feb;63(2):179-81.
Conventional treatment of the cervical factor has proved unsuccessful, with fertility rates under 30% usually quoted. Low-dose estrogen has been one of the main therapies but carries the complication of ovulation interference. It is hypothesized that higher doses of estrogen would improve mucus but would have an even greater adverse effect on ovulation. However, the latter could be obviated by concomitant use of human menopausal gonadotropin (hMG). The hMG would then be monitored by pelvic ultrasound because the ingested estrogen would interfere with estrogen assays. Eighty-two percent of 34 infertile women with no motile sperm on baseline postcoital tests improved their levels after therapy with this high-dose estrogen hMG technique. To date, 56% of these women for whom therapy had previously failed have conceived. Nevertheless, simpler and less expensive techniques should be used initially.
事实证明，对宫颈因素的传统治疗并不成功，通常报道的生育率低于30%。低剂量雌激素一直是主要治疗方法之一，但存在干扰排卵的并发症。据推测，较高剂量的雌激素会改善黏液，但对排卵的不良影响会更大。然而，通过同时使用人绝经期促性腺激素（hMG）可以避免后者的影响。然后通过盆腔超声监测hMG，因为摄入的雌激素会干扰雌激素检测。在34名基线性交后试验中无活动精子的不孕妇女中，82%在采用这种高剂量雌激素hMG技术治疗后其水平得到改善。迄今为止，这些先前治疗失败的妇女中有56%已受孕。尽管如此，最初应使用更简单、更便宜的技术。
