Sodium-dependent lithium ion efflux from murine neuroblastoma and rat glioma cells: a minor pathway for efflux of lithium ions.

Lithium ion efflux by murine neuroblastoma (clone N1E-115) and rat glioma (clone C6) cells was studied to determine the presence of a phloretin-sensitive sodium-lithium countertransport pathway which has been found in human erythrocytes. Although this pathway could be identified in these cultured cells, unlike that in red blood cells, it was a very minor (less than 20%) component of the overall efflux of lithium ions from these cells of nervous tissue origin.